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KMID : 0191120100250101456
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Journal of Korean Medical Science
2010 Volume.25 No. 10 p.1456 ~ p.1461
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Impact of the Metabolic Syndrome on the Clinical Outcome of Patients with Acute ST-Elevation Myocardial Infarction
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Lee Min-Goo
Jeong Myung-Ho
Ahn Young-Keun
Chae Shung-Chull
Hur Seung-Ho
Hong Taek-Jong
Kim Young-Jo
Seong In-Whan
Chae Jei-Keon
Rhew Jay-Young
Chae In-Ho
Cho Myeong-Chan
Bae Jang-Ho
Rha Seung-Woon
Kim Chong-Jin
Choi Dong-Hoon
Jang Yang-Soo
Yoon Jung-Han
Chung Wook-Sung
Cho Jeong-Gwan
Seung Ki-Bae
Park Seung-Jung
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Abstract
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We sought to determine the prevalence of metabolic syndrome (MS) in patients with acute myocardial infarction and its effect on clinical outcomes. Employing data from the Korea Acute Myocardial Infarction Registry, a total of 1,990 patients suffered from acute ST-elevation myocardial infarction (STEMI) between November 2005 and December 2006 were categorized according to the National Cholesterol Education Program-Adult Treatment Panel III criteria of MS. Primary study outcomes included major adverse cardiac events (MACE) during one-year follow-up. Patients were grouped based on existence of MS: group I: MS (n=1,182, 777 men, 62.8±12.3 yr); group II: Non-MS (n=808, 675 men, 64.2±13.1 yr). Group I showed lower left ventricular ejection fraction (LVEF) (P=0.005). There were no differences between two groups in the coronary angiographic findings except for multivessel involvement (P=0.01). The incidence of in-hospital death was higher in group I than in group II (P=0.047), but the rates of composite MACE during one-year clinical follow-up showed no significant differences. Multivariate analysis showed that low LVEF, old age, MS, low high density lipoprotein cholesterol and multivessel involvement were associated with high in-hospital death rate. In conclusion, MS is an important predictor for in-hospital death in patients with STEMI.
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KEYWORD
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Metabolic Syndrome, Prognosis, Myocardial Infarction
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